Fine lines, dryness, rough texture and tired-looking skin are not always problems that require more facial volume.
Sometimes, the skin itself needs better support.

Rejuran is a Korean polynucleotide-based injectable treatment designed to improve overall skin quality by supporting hydration, elasticity and the skin’s natural remodeling process.

At LIV Clinic, every Rejuran treatment is personalized according
to your skin condition, treatment area and aesthetic goals.

When Better Skin Quality Matters More Than More Volume.

Skin aging is not only about wrinkles.
Over time, the skin may become:

Drier Thinner Less elastic Less smooth
More visibly textured More prone to fine lines

Explore Rejuran

WHAT IS REJURAN?

Rejuran is a Korean injectable skin treatment developed by PharmaResearch using purified Polynucleotides, or PN.

PN consists of long chains of nucleotide molecules derived from highly purified salmon-source material.

Rather than working like a conventional dermal filler,

Rejuran is primarily used to support

skin quality and tissue condition.

Polynucleotides form a highly water-attracting,

scaffold-like matrix within the tissue, which may support:

  • Hydration
  • Skin elasticity
  • Tissue remodeling
  • Skin texture
  • Overall skin quality

Rejuran has also been studied in randomized clinical

trials for facial and periocular wrinkles.

HOW DOES REJURAN WORK?

Rejuran works differently from treatments that mainly add volume or relax facial muscles.

1. PN Is Introduced Into the Skin

Small amounts of Rejuran are administered across the targeted treatment area.

2. A Hydrophilic Matrix Forms

Polynucleotides are highly water-binding and can form a scaffold-like environment within tissue.

3. The Skin Remodeling Process Is Supported

Current research suggests PN may support biological processes associated with tissue remodeling, hydration and collagen-related skin structure.

4. Skin Quality Improves Gradually
Over the following weeks, patients may notice improvement in:
Fine lines
Texture
Elasticity
Hydration
Smoothness
Overall skin quality

WHO IS REJURAN FOR?

Rejuran may be considered for people who want to improve skin quality rather than dramatically alter facial shape.

You may be a candidate if you are concerned about:

  • Fine facial lines
  • Fine lines around the eyes
  • Dry or dehydrated-looking skin
  • Uneven skin texture
  • Rough skin
  • Reduced elasticity
  • Thin-looking skin
  • Dull or tired-looking skin
  • Visible pores
  • Early signs of skin aging
  • Selected acne-scar texture

WHAT CAN REJURAN IMPROVE?

Rejuran may be considered for people who want to improve skin quality rather than dramatically alter facial shape.

You may be a candidate if you are concerned about:

  • Fine facial lines
  • Fine lines around the eyes
  • Dry or dehydrated-looking skin
  • Uneven skin texture
  • Rough skin
  • Reduced elasticity
  • Thin-looking skin
  • Dull or tired-looking skin
  • Visible pores
  • Early signs of skin aging
  • Selected acne-scar texture

FINE LINES & TEXTURE

Rejuran for Fine Lines & Uneven Skin Texture

Fine lines often become more noticeable when the skin loses elasticity, hydration and structural support.

Rejuran is commonly used when the goal is not to freeze facial movement or fill a deep crease, but to improve the quality of the skin around the line itself.

Clinical trials of purified PN have reported improvements in measures including:

  • Wrinkle appearance
  • Skin roughness
  • Elasticity
  • Skin texture

For deeper expression lines or structural folds, other treatments may be more appropriate.

UNDER-EYE

Rejuran for the Under-Eye Area

The skin around the eyes is thin, delicate and one of the first areas to show changes in skin quality.

Common concerns include:

  • Fine lines
  • Crepey texture
  • Dryness
  • Reduced elasticity
  • Tired-looking skin

Purified PN has been evaluated in randomized clinical studies for periocular rejuvenation, with improvements reported in elasticity, hydration, roughness and pore-related measures.

Is Rejuran the Same as Under-Eye Filler?

No.Rejuran primarily targets skin quality.

If the main problem is a deep tear trough or structural hollow, dermal filler or another structural treatment may be more appropriate.

ACNE SCARS

Can Rejuran Help Improve Acne-Scar Texture?

Acne scars can involve changes in collagen structure and irregularities beneath the surface of the skin.

Polynucleotide injections have been explored as part of treatment strategies for scar remodeling and skin-quality improvement, and recent expert guidance includes scar remodeling among potential PN applications.

Rejuran may be considered for selected:

  • Shallow atrophic scars
  • Post-acne texture irregularities
  • Skin quality surrounding acne scars

However, significant ice-pick, boxcar or tethered rolling scars usually require treatments specifically selected for scar morphology.

These may include combination approaches rather than Rejuran alone.

TYPES OF REJURAN

Which Type of Rejuran Is Right for You?

The Rejuran family includes different formulations designed for different treatment needs.

REJURAN

Designed for broader facial skin-quality treatment.

Often considered for:

  • Fine lines
  • Texture
  • Elasticity
  • Overall facial skin quality

REJURAN s

A higher-viscosity formulation designed for selected wrinkle-related applications.

REJURAN i

A lower-viscosity Rejuran formulation developed for thin, delicate skin, particularly around the eyes.

Often considered for:

  • Under-eye skin
  • Periocular fine lines
  • Thin or delicate treatment areas

REJURAN HB PLUS

Combines PN + Hyaluronic Acid + Lidocaine.

The manufacturer states that HA is added for hydration and lidocaine is included to improve treatment comfort compared with conventional Rejuran.

Which One Should I Choose?

The appropriate formulation depends on:

  • Treatment area
  • Skin thickness
  • Main concern
  • Desired result
  • Pain sensitivity
  • Previous treatment history

Your LIV Clinic doctor can select the appropriate option after assessing your skin.

RESULTS & TIMELINE

When Will You See a Difference?

Rejuran is designed to create gradual skin-quality improvement rather than an instant facial transformation.

Immediately After Treatment

Small raised injection points, redness or swelling may temporarily be visible.

These early changes are treatment-related and should not be confused with the final result.

Around 2–4 Weeks

Early changes in:

  • Hydration
  • Smoothness
  • Texture

may begin to become noticeable.

Around 1–3 Months

Skin quality may continue to improve as treatment sessions accumulate and tissue remodeling progresses.

Following a Treatment Course

Fine lines, elasticity and overall skin condition may continue to evolve.

Clinical studies have assessed PN outcomes from approximately 2 weeks through several months after treatment, supporting the idea that change is progressive rather than immediate.

Individual results vary.

HOW MANY SESSIONS?

A commonly used starting protocol for PN skin treatment is:

Approximately 3 Sessions

Around 4 Weeks Apart

A large survey of Korean board-certified dermatologists found that three PN sessions spaced approximately four weeks apart was the most commonly recommended approach.

However, your treatment plan may differ depending on:

  • Skin condition
  • Age
  • Treatment area
  • Degree of fine lines
  • Previous procedures
  • Treatment response
  • Desired result

At LIV Clinic, progress should be reassessed rather than assuming every patient needs exactly the same protocol.

PAIN & DOWNTIME

What Is the Downtime?

Rejuran involves multiple small injections into the skin, so temporary discomfort can occur.

You may experience:

  • Pinching
  • Stinging
  • Pressure
  • Tenderness

Comfort measures may be used depending on the formulation and treatment plan.

Rejuran HB Plus specifically combines PN with HA and lidocaine and was developed by the manufacturer partly with treatment comfort in mind.

After Treatment

Temporary reactions may include:

  • Small raised bumps or papules
  • Redness
  • Swelling
  • Tenderness
  • Bruising

BEFORE TREATMENT

Before your appointment, tell your doctor about:

  • Current medications
  • Supplements
  • Allergies
  • Previous injectable treatments
  • Recent laser or energy-based procedures
  • Active acne inflammation
  • Skin irritation or infection
  • Relevant medical conditions
  • Previous reactions to injectable treatments

Do not stop prescription medication unless advised by your prescribing healthcare professional.

Your doctor may provide additional recommendations based on your individual medical history.

AFTERCARE

Rejuran Aftercare

Your doctor may advise you to temporarily avoid:

  • Touching or pressing injection sites unnecessarily
  • Heavy makeup immediately after treatment
  • Intense exercise
  • Saunas and steam rooms
  • Excessive heat
  • Aggressive facial treatments
  • Activities that may irritate the treated skin

Gentle skincare and appropriate sun protection are generally preferred during recovery.

Always follow the specific instructions provided by your LIV Clinic medical team.

WHY LIV CLINIC?

Why Choose Rejuran at LIV Clinic?

Rejuran is not simply about making multiple injections across the face.

The product, formulation, treatment depth and areas selected should all match your skin.

Personalized Skin Assessment

We evaluate your:

  • Skin quality
  • Fine lines
  • Texture
  • Treatment area
  • Previous aesthetic history

before recommending treatment.

Area-Specific Treatment Planning

The under-eye area should not automatically be treated the same way as the cheeks or the rest of the face.

Natural-Looking Philosophy

Our goal is not to make your skin look artificially different.

It is to help it appear healthier, smoother and refreshed while remaining naturally yours.

Multiple Treatment Options

If Rejuran is not the most appropriate treatment for your concern, another skin booster, collagen stimulator, injectable or energy-based treatment may be recommended.

Better Skin Starts With Better Treatment Planning.

FAQ
Frequently Asked Questions About Rejuran

Rejuran uses purified Polynucleotides (PN). PharmaResearch describes its PN material as originating from salmon-derived biological material that undergoes purification.

No. PN and PDRN are related DNA-derived materials but differ in molecular size and formulation. Rejuran injectable products are generally described as PN-based products.

It has historically been classified in some literature as a PN filler, but aesthetically its primary role is not conventional facial contouring or large-volume augmentation. It is generally used as a skin-quality treatment.

Yes, PN has been evaluated in clinical trials for facial and periocular fine lines and wrinkles.

Some clinical studies have reported improvements in pore-related measurements and surface roughness, although individual results vary.

The periocular area is one of the better-studied aesthetic applications of PN, and Rejuran i was specifically developed as a lower-viscosity option for thin skin.

Rejuran’s primary goal is skin quality rather than significant facial volumization.

A common clinical approach is approximately three sessions spaced around four weeks apart, although treatment should be personalized.

Changes are gradual. Some improvement may become noticeable over several weeks, with skin quality continuing to develop following subsequent sessions.

Multiple small injections can cause temporary stinging or discomfort. Rejuran HB Plus includes lidocaine and HA and was developed partly to improve comfort.

Temporary raised injection bumps, swelling, redness or bruising may occur. Recovery varies by treatment area, technique and individual response.

They use different materials and mechanisms. Rejuran uses PN, whereas Juvelook combines PDLLA with HA. Treatment selection should depend on the skin concern and desired result rather than choosing one as universally superior.

Potentially. A survey of Korean dermatologists found PN treatments are frequently incorporated into combination rejuvenation plans, but timing and sequencing should be decided by the treating doctor.

 

IS REJURAN RIGHT FOR YOUR SKIN?

 

At LIV Clinic, our medical team will assess your skin condition,

treatment history and aesthetic goals before recommending

the most appropriate skin-rejuvenation plan.

Healthier-Looking Skin.
Naturally You.

 

 

Book a consultation at LIV Clinic today
and take the first step toward timeless beauty.

SCHEDULE YOUR CONSULTATION TODAY

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